Not sure I fully understand what your doing, but here's a couple thoughts. Is there an easy way to change this permission for all users on the computer ? (he asks, expecting the answer to be 'Use Group Policy' which so far, I have found to be much like tracing each noodle in a vat of spaghetti in hopes of finding a particular tomato seed at the end of one.)
But I'm not the user of the computer, and as soon as a new user gets the computer and logs in, the trust level is set back to MS defaults, instead of where I need it to be to run my machines. I added file//server-name to the trusted sites list in IE, and then also changed the 'launching applications and unsafe files' from Prompt to Enable.
In this case, this extra prompt presents a usability problem. However, when it runs windows insists on splashing up one information-emnpty and fear-mongering chock-full dialogs up, forcing the user to confirm running the program.
I have an small utility that I want to host on a windows server drive (F) and all users to run on startup.